Lars Erik Larsen

University of Copenhagen - Denmark Author

Lars Erik Larsen has worked with virus infections in production animals for the last 20 years. He has been involved in research on swine viruses (diagnostic tools, molecular epidemiology and basic pathogenesis) for the last 10 years. Since 2010 he has been responsible for the diagnostic preparedness program and research regarding animal influenza virus. Lars has participated in several European projects on enzootic swine viruses. He is the leader of the of the enzootic virus research group at DTU and coordinate the national surveillance program on Avian and Swine influenza viruses.

He is currently Professor at University of Copenhagen, Faculty of Medical health Sciences, Department of veterinary and animal health sciences, Frederiksberg C, Denmark

Lars has published more than 80 papers in peer reviewed journals and more than 150 other publications.

Updated CV 31-Jan-2020

Lars Erik Larsen

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PRRS control or elimination in Danish herds – who, how and when

The three most important things in respect to a PRRSV control program are: 1) planning; 2) planning and 3) planning; and the success of the program depends also on three important factors: 1) people; 2) people and 3) people!

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22-Oct-2020tamas-reveszAlthough the control strategy above emphasise the bisecuriy measures as primary action and vaccination as supporting tool only (wich I totally agree), it's strange a little, that despite the publication lately reporting about the severe impact of a recombinant strain originated from 2 MLV strains widely used in Danmark (one of the current auther is co-auther there as well), and several publication proving the higher immunological reaction (Comparison of different vaccination schedules for sustaining the immune response against PRRSV , Diaz et al,2013, The Veterinary Journal) as well as at least same but sometimes even better clinical protection of killed vaccine alone or in prime-boost protocol (Comparison of productivity losses between swine breeding herds adopting killed or attenuated PRRS virus vaccination protocols following PRRS outbreak, Rawal 2020, ISU) , the authers here not even mention it as a possibly safer alternative.

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PRRSV control - example of a successful program

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PRRSV control - example of a failed program

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Figure 2. Use of quarantine in the 69 herds.

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Introduction of replacement gilts to PRRS-positive sow herds

A study was performed including 69 PRRS-positive sow herds with the aim of comparing the use of PRRSV MLV and quarantine facilities with the PRRSV status of replacement gilts at first insemination.

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27-Jun-2017preben-mortensenHey Hooo!
Stop a little
A quarantine is to the best of my knowledge defined as a confined airspace room run strictly all-in-all-out with thorough cleaning, disinfection and drying out between groups.
I do not see any exclusion of rooms called quarantines by the farmer/farm vet(?) but not living up to the true standards of such a facility.
I would like to see the conclusion on quarantine room proper and not something, really nothing, I am sorry to say.

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Figure 1. Schematic view of different approaches in PRRSV positive herds.

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PRRSV control using vaccination and optimized management: three case studies

Although the use of vaccination was effective in stabilizing the sows, the results of these case studies emphasized that elimination of PRRSV from the nursery can only be accomplished if vaccination and partial depopulation/ disinfection are supported by strict implementation of all recommended management procedures, including AI/AO.

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Number of litters positive for SIV by RT-PCR according to parity of the sow

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Swine influenza virus infections in piglets

A relatively high proportion of young piglets in a farrowing unit of a herd with circulating swine influenza virus may be infected by SIV during the first weeks after birth revealing that not all piglets are protected by maternal antibodies.

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Lars Erik Larsen

PRRS control or elimination in Danish herds – who, how and when

PRRSV control - example of a successful program

PRRSV control - example of a failed program

Introduction of replacement gilts to PRRS-positive sow herds

PRRSV control using vaccination and optimized management: three case studies

Swine influenza virus infections in piglets

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