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Inovio Pharmaceuticals Inc. and Plumbline Life Sciences today announced a collaboration to co-develop a novel animal health vaccine for African swine fever (ASF) virus. The vaccine will be developed using Inovio's SynCon® technology and delivered using CELLECTRA® efficacy-enabling devices. Plumbline, based in South Korea, will fund all development and commercialization of the ASF vaccine. Inovio and Plumbline already have a license partnership in animal health fields and Inovio currently holds an approximately 15% equity ownership in Plumbline. As part of this agreement, Inovio will construct and test the ASF vaccine in small animal models. Plumbline will further test the vaccine in larger animal models, including in pig challenge models and further develop to commercialize the vaccine. Financial arrangements were not disclosed.
African swine fever (ASF) is a highly contagious haemorrhagic viral disease of domestic and wild pigs, which is responsible for serious economic and production losses. There is no approved vaccine for ASF currently and the current outbreak in Asia is dramatically threatening the agricultural economies of many Asian countries including China, Vietnam and Korea. The disease is incurable in pigs but innocuous to humans.
Dr. Laurent Humeau, Inovio's Chief Scientific Officer, said "We are extremely pleased to apply Inovio's Synthetic Nucleics platform to develop a vaccine to combat this deadly pig virus. Inovio has a track record of developing novel emerging infectious disease vaccines and we are pleased to work with Plumbline to further test and commercialize an ASF vaccine."
Anthony K. Kim, President and CEO of Plumbline said, "Plumbline is very excited to collaborate with Inovio to advance a new vaccine for this horrible threat for animal health and agriculatural food supplies. Plumbline has a proven track record of commercializing DNA-based therapies for animal health as we have the distinction of having our product for pigs, LifeTide®SW5, already approved in Australia, New Zealand and South Korea. We will devote our full resources to commercialize a vaccine for ASF as rapidly as possible."
The current official estimates count 1 million pigs have already been culled in China but the slaughter data suggest 100 times more could be removed from China's 440 million-strong swine herd in 2019. The U.S. Department of Agriculture forecast in April a decline in China of 134 million head — equivalent to the entire annual output of American pigs — and the worst slump since the department began counting China's pigs in the mid 1970s.
ASF virus, indigenous to Africa, infects only domestic and wild pigs and a species of soft ticks that transmits the disease. The disease emerged in Africa decades ago and have been detected among domestic and wild pigs in Europe. In 2007, the viral disease appeared in the Republic of Georgia and spread through the Caucasus region, and then it eventually reached China in August 2018 and then Mongolia in January and Vietnam in February this year. Japan detected their first case of infectious ASF in late March. The strain of African swine fever spreading in Asia is highly lethal, killing virtually every pig it infects by a hemorrhagic illness reminiscent of Ebola in humans even though it not known to sicken people.
May 15, 2019
