Circovac®

CIRCOVAC PROVIDES STRONG & WIDE PROTECTION
thanks to whole virus PCV2 antigen

• Whole virus antigen provides expression of both ORF1 & ORF2 epitopes^1,2
   
• Induction of strong, broad and long-lasting immunity^1,3
   
• Protection against both PCV2a & PCV2b genotypes^4,5

CIRCOVAC RAPIDLY INCREASES ANTIPCV2 SERONEUTRALIZING ANTIBODY TITRES³

CIRCOVAC INDUCES A STRONG CMI RESPONSE AGAINST BOTH ORF1 & ORF2 PROTEINS¹

CIRCOVAC INDUCES HIGHER IMMUNE RESPONSE
vs subunit vaccines

CIRCOVAC^® induces a higher immune response vs. subunit vaccines (B and C)^4,5
 

HIGHER PCV2-SPECIFIC NEUTRALIZING ANTIBODY TITRES VS. SUBUNIT VACCINES⁴

HIGHER IFNγ-SECRETING CELLS VS. SUBUNIT VACCINES⁴

Different letters (a, b, c) indicate that the groups are signifi cantly (p<0.05) different from each other.

PCV2 viraemia was more reduced vs. subunit vaccines (B and C)^4,5
• No IgG was detected in negative controls

CIRCOVAC IMPROVES
pig health status

By decreasing PCV2 viraemia⁶

By decreasing PCV2 fecal shedding⁶

Piglets were vaccinated on D0 between 17 and 26 days of age

By controlling lymphoid lesions⁷

15 SPF piglets vaccinated at 21 days of age, 15 piglets non –vaccinated

Challenge at 5 weeks of age and euthanasia 29 days after challenge

Weight measurement of lymph nodes

CIRCOVAC BOOSTS PROFITABILITY
thanks to piglets vaccination

CIRCOVAC DECREASES TIME TO SLAUGHTER¹¹

Vs. non-vaccination or competitor vaccine¹¹
• Piglets vaccinated at 3 weeks of age

CIRCOVAC SIGNIFICANTLY REDUCES AVERAGE ANTIMICROBIAL USE¹²

Reduction is observed in farms that switched from other PCV2 vaccines to CIRCOVAC^®

ADD, Animal Daily Dose, is a standardized measure of drug consumption. The lower the value, the lower the drug consumption.

CIRCOVAC IMPROVES FERTILITY
and lowers abortion rate

CIRCOVAC PROVIDES STRONG & WIDE PROTECTION
thanks to whole virus PCV2 antigen

1 270 sow unit
1 962 piglets

• 1 007 control piglets
• 955 piglets born from vaccinated sows

Less “small” piglets at weaning

IMPROVEMENT OF WEANING WEIGHT¹⁴

DISTRIBUTION OF PIGLETS PER WEANING WEIGHT¹⁴

CIRCOVAC PROVIDES STRONG & WIDE PROTECTION
thanks to whole virus PCV2 antigen

CIRCOVAC IMPLEMENTATION

Piglet vaccination

• 0.5 ml from 3 weeks of age
• One shot, IM

Gilt and sow vaccination

• 1 dose = 2 ml
• Primovaccination
  • GILTS: one injection, followed 3 to 4 weeks later by a second injection, at least 2 weeks before mating. One further injection at least 2 weeks before farrowing.
  • SOWS: one injection, followed 3 to 4 weeks later by a second injection, at least 2 weeks before farrowing
• Revaccination
  • One injection at each gestation, at least 2 to 4 weeks before farrowing

References

1. Joisel F, et al. Merial Corporate Symposium. APVS 2009. Tsukuba, Japan. p5-13.
2. Goubier A, et al. IPVS 2008. Durban, South Africa. p40.
3. Chevalier M, et al. IPVS 2010. Vancouver, Canada. p 439.
4. Seo HW, et al. Vet J 2014;200:65-70.
5. Park C, et al. Clin Vaccine Immunol 2014;21:399-406.
6. Fraile L, et al., Vaccine 30, 2012, P 1986-1992.
7. Chevalier M, et al. Proceedings of 22nd IPVS Congress, Jeju, Korea, 2012, vol 2, p 888.
8. Pejsak Z, et al. Comparative Immunology, Microbiology and Infectious Diseases, 2010, 33: e1-e5.
9. Segalés J.Virus Research, 2012, 164: 10-19.
10. Gillepsie TG. 48th annual Georges Young Swine Health and Management Conference, University of Nebraska-Lincoln, 2007, p 1-6.
11. Pedchenko V, et al. ESPHM 2014. Sorrento, Italy. P89, p177.
12. Soegaard R, et al. IPVS 2014. Cancun, Mexico. P352, vol 2, p343.
13. Noirrit et al., 21st IPVS, Vancouver, Canada, p. 436.
14. Brons et al., 2010, 21st IPVS, Vancouver, Canada, p. 374.

DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATION Reconstitute immediately after removal from the refrigerator (or other cold storage). Gilts and sows: Administer one 2 ml dose by deep intramuscular injection in accordance with the following vaccination scheme: Basic vaccination: Gilts: One injection, followed 3 to 4 weeks later by a second injection, at least 2 weeks before mating. One further injection must be given, at least 2 weeks before farrowing. Sows: One injection, followed 3 to 4 weeks later by a second injection, at least 2 weeks before farrowing. Revaccination: One injection at each gestation, at least 2 to 4 weeks before farrowing. Piglets from 3 weeks of age: Administer one 0.5 ml dose by intramuscular injection. ADVICE ON CORRECT ADMINISTRATION To use the vaccine, shake vigorously the vial of antigen suspension and inject its content into the vial of emulsion containing adjuvant. Gently mix before use. The reconstituted vaccine is a homogeneous white emulsion. WITHDRAWAL PERIOD Zero days. SPECIAL STORAGE PRECAUTIONS Keep out of the reach and sight of children. Store and transport refrigerated (2 °C-8 °C). Store in the original package in order to protect from light.

For more details, see the SPC applicable in your country. This page contains information on a veterinary biological product sold in several different countries and areas where it may be subject to different regulatory approvals. Ceva gives no guarantee that the details presented are correct with respect to all locations.In addition, the safety and efficacy data and the withholding periods may be different depending on local regulations. Please consult your veterinarian for further information.