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However the combined resistance to critically important antimicrobials for human medicine remains very low, resistance of Salmonella and Campylobacter bacteria to commonly used antimicrobials continues to be observed frequently in humans and animals, according to a report issued today by the European Food Safety Authority (EFSA) and the European Centre for Disease Prevention and Control (ECDC).
Moreover, there has been an increase in the proportion of Escherichia coli isolates from food-producing animals that exhibit ‘ complete susceptibility ’ or ‘zero resistance’ to key antimicrobials. This, alongside a decrease in the prevalence of E. coli isolates that produce ESBL or AmpC — enzymes which can make some antibiotics ineffective — demonstrates progress in reducing antimicrobial resistance (AMR) in E. coli from food-producing animals across several EU Member States.
For Salmonella, resistance to carbapenems was found in isolates from humans, but not from food-producing animals; for E. coli, carbapenem resistance was detected in isolates from food-producing animals. Although the occurrence of carbapenem resistance is currently reported at very low levels in isolates from both humans and animals, a higher number of countries have reported bacteria producing carbapenemase enzymes in various animal species in recent years. This requires attention and further investigation since carbapenems are a last-resort group of antibiotics and any detection of resistance to them is concerning.
One-third of the countries observed decreasing trends in macrolide resistance in Campylobacter isolates from humans, in particular for C. coli. This is noteworthy as increased resistance to fluoroquinolones means that macrolides are becoming more important for the treatment of severe foodborne infections in humans.
In two-thirds of reporting countries, resistance in isolates from humans to penicillins and tetracyclines decreased over time in Salmonella Typhimurium -which is usually associated with pigs and calves. These antimicrobials are often used to treat bacterial infections in humans and animals.
Antimicrobial resistance remains a major public health concern that needs to be tackled on various fronts and by different actors. Key actions are needed to reduce the emergence and spread of antimicrobial-resistant bacteria. These include promoting prudent use of antimicrobials; supporting improvements in infection prevention and control practices; strengthening research and innovation in developing new antimicrobials; and ensuring that policies and procedures are in place at the national level.
28 February 2024/ EFSA/ European Union.
https://www.efsa.europa.eu
