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The experiment was performed on 100 newly-weaned piglets distributed between five treatments (Control-, Control+, Col1, Col2 and Col3). Control groups received a PW diet without any supplementation while colostrums groups received the same PW diet supplemented with 1% of defatted freeze-dried BC from the 1st (Col1), 2nd (Col2) or 3rd milking (Col3), until the 12th day PW. Then, all the piglets received the same PW diet without any supplementation. On day 5 PW, piglets of ‘Control+’, ‘Col1’, ‘Col2’ and ‘Col3’ treatments were injected IM whit 100 μg LPS/kg BW while ‘Control -’ received a solution of PBS.
Average daily gain and feed ingestion measures were completed with blood analyses (IgA, IgM, IgG, INF-γ, TNF-α, IL-10). BC supplementation induced an increase of ADG in the ‘Col1’ group compared to both ‘Col2’ and ‘Col3’ groups before LPS injection (P<0.05). The LPS challenge induced severe skin inflammations, a decrease of growth performance for 20 days, and important changes of all measured blood parameters 3h post-injection. IgA and IgG concentrations where significantly higher (P<0.05) on day 13, and IgM on day 9 and 13, compared to before injection in the 4 LPS treated groups. BW, ADG and ADFI of both ‘Col1’ and ‘Col3’ were higher (P<0.05) than other two challenged groups at the end of the trial.
In conclusion, the severe effects of LPS masked the potential benefits of BC on ADG and ADFI until day 20. However, higher BW, ADG, and ADFI of both ‘Col1’ and ‘Col3’ observed at the end of the trial suggest a restoration of gut damages promoted by the BC growth factors and a similar effect of 1st and 3rd milking BC on growth performance.
V Gauthier, C Boudry, and A Buldgen, 2009, EAAP 60th Annual Meeting, Barcelona, 457.
