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Genetic characterization of influenza A viruses circulating in pigs in Spain

Phylogenetic analysis revealed that they belonged to the lineages ‘‘Avian-Like’’ H1N1, ‘‘Human-Like’’ H3N2, and ‘‘Human-Like’’ H1N2

5 March 2014
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Researchers of CReSA (Spain) have studied the genetic characterization of influenza A viruses circulating in pigs and isolated in north-east Spain during the period 2006–2007. Phylogenetic analysis revealed that they belonged to the lineages ‘‘Avian-Like’’ H1N1, ‘‘Human-Like’’ H3N2, and ‘‘Human-Like’’ H1N2, showing tight relationships with early or contemporary strains described in Europe. Notably, one virus of the H1N2 subtype showed genetic and antigenic divergence with the European contemporary strains or vaccinal strains of the same subtype, suggesting that some local and divergent clusters of the virus may pass unnoticed in routinary subtyping. Finally, analysis on the entire pattern of genome segments suggested that a second reassortment event could have influenced the evolution of that divergent H1N2 strain

Swine influenza virus (SwIV) is one of the most important pathogens involved in the swine respiratory disease complex. Recent serological surveys showed a high prevalence of swine influenza strains belonging to the H1N1, H1N2 and H3N2 subtypes circulating in pigs in Spain. However, little is known about their genome sequence.

Baratelli M, Córdoba L, Pérez LJ, Maldonado J, Fraile L, Núñez JI, Montoya M. Genetic characterization of influenza A viruses circulating in pigs and isolated in north-east Spain during the period 2006-2007. Res Vet Sci. 2013 Dec 13. doi: 10.1016/j.rvsc.2013.12.006. [Epub ahead of print]

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