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While sera PO4 did not differ between treatment groups at either time point, a dose response was noted in sera Ca (P < 0.05) and PTH (P < 0.05) concentrations at d 6, with adequate animals having the lowest sera PTH concentrations and correspondingly higher circulating Ca when compared to the other groups. Although, the tibias of animals receiving the PO4 adequate diet were larger (P < 0.05) and thicker (P < 0.1) than the bones of those animals receiving excess PO4, ash percentage did not differ between groups. Proliferation of MSC treated for 24 h in sera from each group was effected by PO4 status (P < 0.1) of the animal and tended to be influenced by PO4 status of the sera. Because circulating PO4 did not differ between groups, the changes in bone measures, sera mineral and hormone concentrations, and MSC proliferation would suggest possible differences in PO4 utilization. Additional research is needed to further clarify how PO4 status affects MSC activity and the subsequent alterations in bone integrity.
LS Alexander, BS Seabolt, and CH Stahl, 2010. Journal of Animal Science, 88 (E-Suppl. 2):670.
