Sanguinarine does not influence availability or metabolism of tryptophan in pigs

Sanguinarine does not affect tryptophan metabolism and this does not improve pig performance.

Sanguinarine product, a phytogenic feed additive derived from the rhizomes of Sanguinaria canadensis has been suggested to improve growth performance of pigs by tryptophan sparing due to inhibition of L-aromatic amino acid decarboxylase by its active ingredient Sanguinarine. Therefore, the aim of the present study was to evaluate the effect of supplementation of Sanguinarine product to diets adequate or deficient in tryptophan on growth performance in pigs. In two replicate trials, 24 pigs were fed one of four experimental diets consisting of a basal diet deficient in tryptophan, the basal diet deficient in tryptophan supplemented with 50 mg Sanguinarine product per kg diet, the basal diet supplemented with 1 g tryptophan per kg diet and the basal diet supplemented with 1 g tryptophan and 50 mg Sanguinarine product per kg diet over a period of three weeks.

Compared to the animals receiving the tryptophan adequate diets, pigs fed the tryptophan deficient diets showed a pronounced decrease in feed intake, resulting in decreased daily gain and poorer feed conversion. Supplementation of Sanguinarine product to tryptophan adequate and to tryptophan deficient diets had no effect on feed intake, daily gain and feed conversion.

Based on the growth performance data, the results of this study, indicate that supplementation of Sanguinarine product to pig diets may not have any beneficial effect on tryptophan availability or metabolism.

R Blank, B Müller-Siegwardt, S Wolffram. 2010, Livestock Science, 134:24-26.

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24-Feb-2012

Roman RodriguezI would very apreciate if you send me a copy of the article citated Sanguinarine does not influence availability or metabolism of tryptophan in pigs

24-Feb-2012

jordi-guillaumet_1Hi Roman,
the article can be found here:
http://www.journals.elsevierhealth.com/periodicals/livsci/article/S1871-1413%2810%2900298-2/abstract

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Sanguinarine does not influence availability or metabolism of tryptophan in pigs

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