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Introduction - To investigate whether Swine Torque teno sus virus type 1 (TTSuV1) and 2 (TTSuV2) viral loads are modulated by the presence of other concomitant viral diseases such as porcine circovirus type 2 associated diseases (PCVD) and classical swine fever (CSF).
Materials and methods - In the first study, serum samples from 45 pigs suffering from postweaning multisystemic wasting syndrome (PMWS) and 34 cases of porcine dermatitis and nephropathy syndrome (PDNS) were selected together with those of 34 age-matched healthy pigs. In a second study, 56 healthy pigs were challenged with a highly pathogenic strain of CSF virus (CSFV) and they were grouped into 4 categories based on their immune response to CSFV and clinical outcome (no, mild, moderate and severe clinical signs). These pigs were bled before the challenge and at the day of necropsy. Quantitative TTSuV1
and TTSuV2 polymerase chain reaction (qPCR) was used to analyze serum extracted DNA from both studies.
Results - TTSuV2 was highly prevalent in all studied groups while TTSuV1 showed lower prevalence. Significant differences were observed when comparing TTSuV2 viral loads in PMWS (p<0.05) and PDNS (p<0.06) affected animals with healthy animals. Such differences were not observed for TTSuV1. In CSFV infected animals only significant differences in viral loads were observed for TTSuV2 in moderate CSF overall outcome and when comparing this group to non-infected animals at the time of necropsy.
Conclusion - These studies indicate that TTSuV2 load in serum is up-regulated in PCVD and CSF, while this did not happen with TTSuV1. Obtained results suggest that immunosuppression may differentially affect the replication capabilities of TTSuVs.
Aramouni M., Segalés J., Nieto D., Ganges L., Tarradas J., Jiménez-Melsió A., Muñoz M., Kekarainen T. Torque Teno sus virus type 2 (TTSuV2) loads in serum are increased in the background of diseases affecting the immune system. 4th European Symposium of Porcine Health Management. 2012.