X
XLinkedinWhatsAppTelegramTelegram
0
Read this article in:

Vaccination influences the evolution of classical swine fever virus

Vaccination may affect strain diversity and immune escape through recombination and point mutation.

11 July 2014
X
XLinkedinWhatsAppTelegramTelegram
0

The Classical swine fever virus (CSFV) is composed of two clades, according to phylogenetic estimates. Attenuated live vaccine such as HCLV, has been widely used to protect pigs from CSFV, but the influence of vaccination on the evolution of CSFV has not been studied.

We conducted a systemic analysis of the impact of vaccination on the evolution of CSFV by comparing vaccine-related and non-vaccine-related CSFV groups. We found that vaccination may affect strain diversity and immune escape through recombination and point mutation. We also found that vaccination may influence the population dynamics, evolutionary rate and adaptive evolution of classical swine fever virus. Our evidence suggests that the vaccination might also change host adaptation through influencing codon usage of the virus in swine. These findings suggest that it is necessary to avoid excessive use of CSFV attenuated vaccines.

Ji W, Niu DD, Si HL, Ding NZ, He CQ. Vaccination influences the evolution of classical swine fever virus. Infect Genet Evol. 2014 Apr 18;25C:69-77. doi: 10.1016/j.meegid.2014.04.008.

Article Comments

This area is not intended to be a place to consult authors about their articles, but rather a place for open discussion among pig333.com users.
Leave a new Comment

Access restricted to 333 users. In order to post a comment you must be logged in.

You are not subscribed to this list Swine News

Swine industry news in your email

Log in and sign up on the list

Related articles

You are not subscribed to this list Swine News

Swine industry news in your email

Log in and sign up on the list